CPN Publications
Effects of Drug Abuse and Genetics on Impulsive Choice
Karen G. Anderson, Ph.D., Subproject Principal Investigator
Full papers (funded 2002-2003):
1. Anderson KG, Woolverton WL* Effects of clomipramine on self-control choice in Lewis and Fischer 344 rats. Pharmacol Biochem Behav 2005;80(3):387-93.
Pubmed link
Voltage-gated Calcium Channels and NMDA Receptor Subunits in Locus Coeruleus of Alcoholics
Beata Karolewicz, Ph.D., Small Grant Principal Investigator
Full papers (CPN-supported):
1. Karolewicz B, Klimek V, He Zhu, Szebeni K, Nail E, Stockmeier CA, Johnson L, Ordway GA. Effects of depression, cigarette smoking, and age on monoamine oxidase B in amygdaloid nuclei. Brain Res 2005;1043:57-64.
Pubmed link
2. Karolewicz B, Szebeni K, Stockmeier CA, Konick L, Overholser JC, Jurjus G, Roth BL, Ordway GA. Low nNOS protein in the locus coeruleus in major depression. J Neurochem 2004;91:1057-1066.
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3. Karolewicz B, Stockmeier CA, Ordway GA. Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression. Neuropsychopharmacology 2005;30:1557-67.
Pubmed link
Abstracts reflecting ongoing studies (CPN-supported):
1. Zhu He, Karolewicz B, Nail E, Szebeni K, Stockmeier CA, Overholser JC Jurjus G, Roth BL, Ordway GA. Analysis of GABA-A receptors in the locus coeruleus in major depression. Soc Neuroscience 2004; Abstract #799.15.
2. Karolewicz B, Szebeni K, Nail E, Hawkins W, Stockmeier CA, Roth BL, Overholser JC, Jurjus G, Ordway GA. Dopamine catabolic enzymes in amygdala in major depression. Soc Neuroscience 2004;30:Abstract #799.10.
3. Karolewicz B, Szebeni K, Nail E, Hawkins W, Stockmeier CA, Ordway GA. nNOS immunoreactivity in major depression: does brain pH affect nNOS protein integrity in postmortem human tissue? Biol Psychiatry 2004; 54:841.
4. Ordway GA, Karolewicz B, Zhu H, Stockmeier CA, Hawkins W, Nail E, Szebeni K. Extensive histological mapping of the entire human amygdaloid complex: measurement of monoamine oxidase B in major depression. Biol Psychiatry 2004; 54:731.
5. Karolewicz B, Romero MS, Szebeni K, Stockmeier CA, Johnson L, Ordway GA. NMDA receptor subunits in the locus coeruleus in schizophrenics. Program No. 675.15. 2005 Abstract Viewer/Itinerary Planner. Washington, DC Society for Neuroscience.
Role of µ-Opioid System In Methamphetamine Sensitization
Tangeng Ma, Ph.D., Subproject Principal Investigator
Full papers (CPN-supported):
1. Lu-Tai Tien, Lir-Wan Fan, Chiharu Sogawa, Tangeng Ma, Horance H. Loh, and Ing K. Ho. Changes in acetylcholineaterse activity and muscarinic receptor bindings in µ-opioid receptor knockout mice. Mol Brain Res 2004;126:38-44.
Pubmed link
2. Tien LT, Fan LW, Ma T, Loh HH, Ho IK. Increased diisopropylfluorophosphate-induced toxicity in µ-opioid receptor knockout mice. J Neurosci Res 2004; 78(2):259-267.
3. Lu-Tai Tien, Lir-Wan Fan, Tangeng Ma, Horance H. Loh, and Ing K. Ho. Roles of µ-opioid receptors in development of tolerance to diisopropylfluoro-phosphate (DFP). J Toxicol Sci 2005; 30:43-59.
4. Chi-Tso Chiu, Tangeng Ma, and Ing K. Ho (2005) Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone. Brain Res Bull, in press.
Pubmed link
Other full papers:
1. Zhu H, Zhou W, Li XR, Ma T, Ho IK, and Rockhold RW. Methyl parathion increases neuronal activities in the rat locus coeruleus. J Biomed Sci 2004;11:732-738.
Pubmed link
2. K. Ho, Lir-Wan Fan, Seong-Youl Kim, Tangeng Ma, and Robin W. Rockhold. Neurochemical alterations in physical dependence on butorphanol. J Appl Pharmacol 2004, in press.
Abstracts reflecting ongoing studies (CPN-supported):
1. Tangeng Ma, Akira Ochiai, Chi-Tso Chiu, Rob W. Rockhold, Horace H. Loh, and Ing K. Ho (2004) Effects of acute methamphetamine treatment on µ-opioid agonist-stimulated [35S]GTPgammaS binding in µ-opioid receptor knockout mice. Soc Neuroscience, 34th Annual Meeting, San Diego, Abstract #915.6.
2. Lu-Tai Tien, Akira Ochiai, Rob W. Rockhold, Horace H. Loh, Ing K. Ho, and Tangeng Ma (2004) Effects of acute methamphetamine treatment on dopamine receptors in µ-opioid receptor knockout mice. Soc Neuroscience, 34th Annual Meeting, San Diego, Abstract #915.5.
3. Chi-Tso Chiu, Tangeng Ma, and Ing K. Ho (2005) Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone. The Federation of American Society for Experimental Biology Annual Meeting, San Diego, April 2005. (on CD ROM, The FASEB Journal, 19, Abstract #311.9.
Pubmed link
Alterations of Cortical Synaptic Markers in Alcohol Dependence
Javier Miguel-Hidalgo, Ph.D., Subproject Principal Investigator
Full papers (CPN-supported):
1. Miguel-Hidalgo, J.J. Lower packing density of glial fibrillary acidic protein-immunoreactive astrocytes in the prelimbic cortex of alcohol-naive and alcohol-drinking alcohol-preferring rats as compared with alcohol-nonpreferring and Wistar rats. Alcohol Clin. Exp Res 2005;29:766-772.
Pubmed link
2. Rajkowska G, Miguel-Hidalgo J.J., Dubey P, Stockmeier CA and Krishnan RR. Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients. Biol Psychiatry 2005, in press.
Pubmed link
3. Miguel-Hidalgo, JJ, Wanzo, V. Koussih, B. Withdrawal from free-choice ethanol consumption increases the packing density of GFAP and glutamine synthetase immunoreactive astrocytes in alcohol P rats. Alcohol Clin Exp Res 2005;25(9):16A.
4. Miguel-Hidalgo, JJ. Withdrawal from free-choice ethanol consumption results in increased packing density of glutamine synthetase-immunoreactive astrocytes in the prelimbic cortex of alcohol-preferring rats. Alcohol Alcohol 2006 (in press).
Other full papers:
1. Miguel-Hidalgo J.J., Dubey P, Shao, Q., Stockmeier CA, and Rajkowska G. Unchanged packing density but altered size of neurofilament immunoreactive neurons in the prefrontal cortex in schizophrenia and major depression. Schizophrenia Res 2005, in press.
Pubmed link
2. Si, X.X., Miguel-Hidalgo, J.J., O'Dwyer, G., Stockmeier, C.A., and Rajkowska, G. Age-Dependent Reductions in the Level of Glial Fibrillary Acidic Protein in the Prefrontal Cortex in Major Depression. Neuropsychopharmacology 2004;29:2088-2096.
Pubmed link
Abstracts reflecting ongoing studies (CPN-supported):
1. Miguel-Hidalgo, J.J., Koussih, B, Wanzo, V. Packing density of GFAP-positive astrocytes in the prelimbic cortex of alcohol-naïve P rats is lower than in Wistar rats. Program No. 234.17. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online.
2. Miguel-Hidalgo, J.J, Nithuairisg S., Shao Q., Stockmeier, C. and Rajkowska, G. Normal Aging and the Distribution of the Cell-Adhesion Protein ICAM-1 in the Orbitofrontal Cortex. Biol Psychiatry 2004;57(8S):427.
3. G. O'Dwyer, P. Dubey, Q. Shao, J. Stuckey, S. NiThuairisg, J.J. Miguel-Hidalgo, C.A. Stockmeier, R.R. Krishnan, G. Rajkowska. Age-dependent cellular changes in the prefrontal cortex in postmortem tissue from depressed subjects. Program No. 98.11. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online.
4. Craig A. Stockmeier, M.D. Saenz, E.Smith, J.J. Miguel-Hidalgo, L Friedman, Grazyna Rajkowska. Volume of the Midbrain Dorsal Raphe Nucleus in Major Depressive Disorder (MDD). Biol Psychiatry 2004;57(8S):116S.
5. Rajkowska G, Miguel-Hidalgo JJ, Dubey P, Stockmeier CA, Krishnan, RR. Neuronal pathology in orbitofrontal cortex in elderly subjects with MDD is more severe than that in age-matched control subjects. Biol Psychiatry 2005, in press.
6. Miguel-Hidalgo JJ, Wanzo V, Koussih B. Withdrawal from free-choice ethanol consumption increases the packing density of GFAP and glutamine synthetase immunoreactive astrocytes in alcohol P rats. Alcohol Clin Exp Res 2005;29(5):16A.
Neurobehavioral Effects of Early Exposure to Psychotherapeutic Agents
Ian A. Paul, Ph.D., Subproject Principal Investigator
Full papers (CPN-supported):
1. Maciag, D., Simpson, K.L., Coppinger, D., Lu, Y., Wang, Y., Lin, R.C.S., Paul, I.A. Neonatal antidepressant exposure has lasting effects on behaviour and serotonin circuitry. Neuropsychopharmacology, in press.
Pubmed link
Abstracts reflecting ongoing studies (CPN-supported):
1. Maciag, D., Coppinger, D. and Paul, I.A. Chronic treatment with imipramine reverses changes in adult locomotor and male sexual behavior produced by neonatal exposure of rats to serotonin reuptake inhibitors (SRIs). Washington, DC: Society for Neuroscience, 2004 Abstract Viewer/Itinerary Planner, Program No. 912.1.
2. Coppinger, D., Simpson, K.L., Maciag, D., Lin, R.C.S. and Paul, I.A. Neonatal treatment with serotonin reuptake inhibitors (SRIs) profoundly reduces tyrosine and tryptophan hydroxylase immunoreactivity in rat caudate-putamen and dorsal raphe n. Washington, DC: Society for Neuroscience, 2004 Abstract Viewer/Itinerary Planner, Program No. 912.2.
3. Maciag, D., Simpson, K.L., Coppinger, D., Lu, Y., Wang, Y., Lin, R.C.S. and Paul, I.A. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Society for Biological Psychiatry 2005; 57:Abstract #769 (Program Supplement).
Pubmed link
4. Coppinger D, Maciag D, Gibson L, Paul IA. Reversal of sexual behavior deficits but not immobility in the forced swim test with adult imipramine treatment after neonatal clomipramine administration. Biol Psychiatry 2004;55:6S.
5. Paul IA. Evidence of altered calcium signaling in depression: predictive value of the ability to modulate calcium signaling in screening of drugs for antidepressant activity. Biol Psychiatry 2004; 55:13S.
Assessing THC Pro-drugs in Transmucosal Patch Delivery Formulations for the Treatment of Neuropathological Conditions
Michael A. Repka, D.D.S., Ph.D., Small Grant Principal Investigator
Full papers (CPN-supported):
1. Repka MA, Munjal M, ElSohly MA, Ross S. Temperature stability and bioadhesive properties of Delta9-tetrahydrocannabinol incorporated hydroxypropyl cellulose polymer matrix systems. Drug Dev Ind Pharm 2005;31(4).
Pubmed link
2. Prodduturi S, Manek RV, Kolling WM, Stodghill SP, Repka MA. Solid-state stability and characterization of hot-melt extruded poly(ethylene) oxide films. J Pharm Sci, in press.
Pubmed link
3. Repka MA, Munjal M, Prodduturi S, Mididoddi P. Matrix and reservoir-based oral transmucosal systems: tailoring delivery solutions. Am J Drug Del 2004;2(3):173-192.
Abstracts reflecting ongoing studies (CPN-supported):
1. Prodduturi S, Manek RV, Kolling WM, Stodghill SP, Repka MA. Hot-melt extruded polymeric films for transmucosal drug delivery: tailoring properties using polymer blends. The AAPS Journal Vol. 6, No. 4, Abstract T3296 (2004).
2. Prodduturi S, Urman KL, Otaigbe J, Stodghill SP, Repka MA. Dynamic mechanical analysis: determining the mechanical properties and glass transition temperatures of hot-melt extruded hydroxypropyl cellulose films. The AAPS Journal Vol. 6, No. 4, Abstract R6179 (2004).
3. Munjal M, Stodghill SP, Repka MA. Formulating solid dispersions of amorphous poorly water-soluble tetrahydrocannabinol. The AAPS Journal Vol. 6, No. 4, Abstract M1257 (2004).
4. Munjal M, Repka MA. Improving stability of amorphous tetrahydrocannabinol in polymeric systems. The AAPS Journal Vol. 6, No. 4, Abstract R6086 (2004).
5. Munjal M, Repka MA. Chemical stabilization of an unstable tetrahydrocannabinol pro-drug in polymeric matrix systems produced by a hot-melt method. The AAPS Journal Vol. 6, No. 4, Abstract R6085 (2004).
Galanin in Locus Coeruleus-Ventral Tegmental Area Axons
Kimberly L. Simpson, Ph.D., Subproject Principal Investigator
Full papers (CPN-supported):
1. Maciag, D., Simpson, K.L., Coppinger, D., Lu, Y., Wang, Y., Lin, R.C.S., Paul, I.A. Neonatal antidepressant exposure has lasting effects on behaviour and serotonin circuitry. Neuropsychopharmacology, in press.
Pubmed link
Abstracts reflecting ongoing studies (CPN-supported):
1. Simpson, K.L., Lu, Y.F., Wang, Y., May, J., Patel, N. and Lin, R.C.S. Galanin innervation of rat ventral tegmental area by locus coeruleus. Society for Neuroscience Abstract, Program # 45.5, 2004.
2. Lu, Y.F., Wang, Y., Simpson, K.L. and Lin, R.C.S. Galaninergic projections from locus coeruleus to dorsal raphe in the rat. Society for Neuroscience Abstract, Program # 45.6, 2004.
3. Coppinger, D., Simpson, K.L., Maciag, D., Lin, R.C.S. and Paul, I.A. Neonatal treatment with serotonin reuptake inhibitors (SRIs) profoundly reduces tyrosine and tryptophan hydroxylase immunoreactivity in rat caudate-putamen and dorsal raphe nucleus. Society for Neuroscience Abstract, Program # 912.2, 2004.
4. Kuo, C.C., Lu, Y.F., Wang, Y., Simpson, K.L. and Lin, R.C.S. The effect of trigeminal subnucleus interpolaris lesions on the receptive field property of zona incerta neurons. Society for Neuroscience Abstract, Program # 978.11, 2004.
5. Wang, Y., Kuo, C.C., Simpson, K.L. and Lin, R.C.S. Expression of connexin 36 immunoreactivity in rodent zona incerta. Society for Neuroscience Abstract, Program # 978.12, 2004.
6. Maciag, D., Simpson, K.L., Coppinger, D., Lu, Y., Wang, Y., Lin, R.C.S. and Paul, I.A. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Society for Biological Psychiatry 2005; 57:Abstract #769 (Program Supplement).
Pubmed link
The Role of Hypocortisolism in the Development of Post-Traumatic Stress Disorder
Laura Stoppelbein, Ph.D., Small Grant Principal Investigator
Other Full papers:
1. Stoppelbein L, Greening L, Elkin TD. Risk of posttraumatic stress symptoms: a comparison of child survivors of pediatric cancer and parental bereavement. J Pediatr Psychol, in press.
Pubmed link
2. Stoppelbein L, Greening L, Jordan SS, Elkin TD, Moll G, Pullen J. Factor analysis of the pediatric symptom checklist with a chronically ill pediatric population. J Dev Behav Pediatr 2005;26:349-55.
Pubmed link
3. Greening L, Stoppelbein L, Chandler CC, Elkin TD. Predictors of children’s and adolescents’ risk perception. J Pediatr Psychol 2005;30:425-35.
Pubmed link
4. Greening L, Chandler CC, Stoppelbein L, Robison L. Risk perception: using conditional versus general base rates for risk communication. J Appl Soc Psychol, in press.
5. Greening L, Stoppelbein L, Dhossche D. Psychometric evaluation of a measure of Beck’s negative triad for youth: applications for African-American and Caucasian youths. Depress Anxiety 2005;21:161-9.
Pubmed link
6. Greening L, Stoppelbein L, Moll G, Palardy N, Hocking M. Intrinsic motivation and glycemic control in adolescents with Type I diabetes. Diabetes Care 2004;27:1517.
Pubmed link
7. Jordan SS, Hilker KA, Stoppelbein L, Elkin TD, Applegate H, Iyer R. Nocturnal enuresis and psychosocial problems in pediatric sickle cell disease and sibling controls. J Dev Behav Pediatr 2005;26:404-11. Pubmed link
Neuronal Mechanisms Underlying Opioid Addiction
Hong Zhu, M.D., Ph.D., Small Grant Principal Investigator
Other Full papers:
1. Zhu H, Zhou W, Li X, Ma T, Ho IK., Rockhold RW. Methyl parathion increases neuronal activities in the rat locus coeruleus. J Biomed Sci 2004;11:732-738.
Pubmed link
1. Zhu H, Zhou W. Effects of chronic morphine treatment on the synchronous oscillatory discharges in the locus coeruleus. Society for Neuroscience 2004, Program No. 357.12.
Agmatine, Neuroprotection and Depression
Meng-Yang Zhu, M.D., Ph.D., Subproject Principal Investigator
Full papers (CPN-supported):
1. Zhu MY, Wang, WP, Baldessarini RJ, Kim KS: Effects of desipramine treatment on tyrosine hydroxylase gene expression in cultured neuroblastoma cells and rat brain tissue. Mol Brain Res 2005;133:167-175.
Pubmed link
2. Zhu MY, Wang, WP, Iyo AH, Kim KS: Age-associated changes in mRNA levels of Phox2, norepinephrine transporter and dopamine ß-hydroxylase in the locus coeruleus and adrenal glands of rats. J Neurochem, 2005 (in press).
Pubmed link
Abstracts reflecting ongoing studies (CPN-supported):
1. W.P.Wang, Soundar Regunathan, M.Y. Zhu. The neuroprotective effect of agmatine against NMDA and dexamethasone in the hippocampal neurons: immuno- and TUNEL staining study. Society for Neuroscience, San Diego, CA, October 23-27, 2004.