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Research Interests
Dr. de Wit’s research focuses on the
physiological, subjective (i.e., mood-altering) and behavioral
effects of drugs in healthy human volunteers. Current projects
in her laboratory include: i) investigating individual
differences in responses to drugs, ii) examining interactions
between steroid hormones and drugs, and iii) studying the effects
of drugs on impulsive behavior and risk-taking. These studies may
improve our understanding of the mechanisms underlying motivated
behavior and of the processes underlying drug and alcohol
use. Ultimately, we hope that studies such as these will lead
to better approaches to preventing and treating drug
abuse.
Selected Publications
Young, E.M.,
Mahler, S.V., Chi, H., de Wit, H:
Mecamylamine and ethanol preference in healthy volunteers.
Alcoholism: Clinical and Experimental Research, in
press.
Acheson, A., Burnworth, J.E., de Wit,
H., Richards, J.B.: Effects of acute and chronic
amphetamine on impulsive behavior in rats: Modulation by
conditioned reinforcers. Psychopharmacology,
in press.
Soderpalm, A.H.V., Lindsay, S., Purdy, R., Hauger,
R.H. and de Wit, H.: Administration of
progesterone produces mild sedative effects in men and women.
Psychoneuroendocrinology
29:339-354, 2004.
Zernig, G., de Wit,
H., Telser, S., Nienhusmeier, H., Wakonigg, G.,
Sturm, K., Berger, I., Kemmler, G., Saria, A.: Subjective effects
of slow-release bupropion vs. caffeine as determined in a
quasi-naturalistic setting. Pharmacology 70:206-215,
2004.
Reynolds, B., Richards, J.B., Dassinger, M.,
de Wit, H.:Therapeutic doses of diazepam do not
increase impulsive behavior in humans. Pharmacology,
Biochemistry and Behavior 79:17-24, 2004.
Kieres, A.K., Hausknecht, K.A., Farrar, A.M.,
Acheson, A., de Wit, H., Richards, J.B.: Effects
of morphine and naltrexone on impulsive decision making in rats.
Psychopharmacology 173:167-74,
2004.
Alsene, K.M., Li, Y., Chaverneff, F. and de Wit,
H.: Role of abstinence
and visual cues on food and smoking craving. Behavioral
Pharmacology 14:145-151, 2003.
Chi, H. and de Wit, H.:
Mecamylamine attenuates the subjective stimulant-like effects of
alcohol in social drinkers. Alcoholism: Clinical and
Experimental Research 27(5):780-786,
2003.
McDonald, J., Schleifer, L., Richards, J.B., and de Wit,
H.: Effects of delta
9-tetrahydrocannabinol on behavioral measures of
impulsivity in humans. Neuropsychopharmacology
28:1356-1365, 2003
Shaham, Y., Shalev, U. , L.
Lu, de Wit,
H., and
Stewart, J. : The reinstatement
model of drug relapse: History, methodology and major
findings. Psychopharmacology, 168: 3-20, 2003.
de Wit, H., Nikolayev,
L. , Soderpalm, A.H.V., Young, E.: Effects of acute social stress on alcohol
consumption in healthy subjects. Alcoholism: Clinical and
Experimental Research 27:2003.
Alsene, K.M., Deckert, J.
and de Wit,
H.: Increased anxiety after
acute caffeine associated with adenosine A2A receptor polymorphism.
Neuropsychopharmacology 28:1694-1702,
2003.
de
Wit, H., Enggasser, J.L., and Richards,
J.B.: Acute administration of
d-amphetamine decreases impulsivity in healthy
volunteers. Neuropsychopharmacology 27:813-825,
2002.
Crean, J., Richards, J.B.,
and de Wit, H.: Impulsive behavior in men with and
without a family history of alcoholism: Effects of tryptophan
depletion. Behavioral Brain Research 136:2 349-57,
2002.
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