Research Interests

Dr. Muly received his M.D. in 1993, his Ph.D. in 1992 from Duke University and his residency training in psychiatry at Yale University. He was trained in the laboratories of David Fitzpatrick and Patricia Goldman-Rakic. His research activities are currently focused on elucidating the structural basis for cortical function. Neuroanatomical techniques, including electron microscopic approaches and immunohistochemistry, are utilized by Dr. Muly to relate the circuitry of the prefrontal cortex to the molecular machinery of neurotransmission. He is currently examining the D₁ receptor and its signal transduction proteins (protein phosphatase-1 alpha and -1gamma1). He is presently funded by the National Science Foundation (NSF) on a joint project with Dr. Martha Bickford and Dr. Paul J. May entitled “Synaptic Organization of the Primate Pulvinar Nucleus”. In addition to maintaining an active research laboratory, Dr. Muly devotes a significant amount of time to his clinical practice. Although his scientific work has focused on issues relevant to schizophrenia, his clinical practice is with a population of patients with a broad range of diagnoses. Dr. Muly's research is funded by grants from the National Institute of Mental Health, NARSAD Young Investigator Award, and the Stanley Foundation (SMRI).

Selected Publications

Muly, III, E.C., Greengard, P. and Goldman-Rakic, P.S.: Distribution of protein phosphatases- 1 alpha and -1gamma1 and the D₁ receptor in primate prefrontal cortex: evidence for discrete populations of spines. Journal of Comparative Neurology, 440: 261-70, 2001.

Goldman-Rakic, P.S., Muly, III, E.C. and Williams, G.V.: D₁ receptors in prefrontal cells and circuits. Brain Research-Brain Research Reviews, 31: 295-301, 2000.

Krimer, L.S., Muly, III, E.C. and Williams, G.V.:  Dopaminergic regulation of cerebral cortical microcirculation. Nature Neuroscience, 1: 286-9, 1998.

Muly, III, E.C., Szigeti, K. and Goldman-Rakic, P.S.: D1 receptor in interneurons of macaque prefrontal cortex: Distribution and subcellular localization. Journal of Neuroscience, 18: 10553-65, 1998.

Muly, III, E.C., Signal transduction abnormalities in schizophrenia: The Camp System. Psychopharmacology Bulletin, 36:92-105, 2002.

Muly, III, E.C., Maddox, M. and Smith, Y.: Distribution of mGluR1a and mGluR5 immunolabeling in primate prefrontal cortex. J. Comp. Neurol., 467:521-535, 2003.

Waugh, J.L., Lou, A.C.,  Eisch, A.J.,  Monteggia, L.M., Muly,E.C. Gold, S.J.: Regional, cellular and subcellular localization of RGS10 in rodent brain. J Comp Neurol. (in press)

Muly, E. C.,  Allen, P., Mazloom, M., Aranbayeva, Z., Greenfield, A.T.,  Greengard, P.:  Subcellular distribution of neurabin immunolabeling in primate prefrontal cortex: Comparison with spinophilin.  Cerebral Cortex (in press)

Muly, E. C., Smith, Y., Allen, P., Greengard, P.: Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex:Localization to and within dendritic spines.  J. Comp. Neurol., 469:185-197, 2004.